University at Buffalo, The State University of New York
  • welcomeWelcome to HJKRI
  • feltriFeltri Lab
  • paezPaez Lab
  • parkPark Lab
  • wrabtzWrabetz Lab
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Basic Science

Mission

To develop a multi-disciplinary approach to understand how myelin is formed, how axons and myelin are damaged in disease, and how they may be repaired.

Objectives

  • To study myelin formation as a source for strategies of myelin repair
  • To study consequences of myelin damage—common to all diseases of myelin—such as inflammation or neurodegeneration
  • To provide better cellular and animal models for identifying mechanisms of disease
  • To exploit models to perform preclinical studies of therapies
  • To translate the research of HJKRI into prognostic, diagnostic and treatment application

Clinical Science

Mission

To provide better diagnostic, prognostic and therapeutic options for Krabbe Leukodystrophy patients.

Objectives

  • To develop initiatives to maximize the success of the Newborn Screening program for Krabbe Disease
  • To increase understanding of various types of Krabbe Disease, determine which biochemical, genetic, and neurodiagnostic tests predict phenotype
  • To educate physicians about Krabbe Disease and Newborn Screening
  • To develop natural history studies, clinical evaluation and treatment protocols for Krabbe Disease